I just upgraded to Karmic Koala and I'm NOT impressed - My mouse and keyboard have become unresponsive and sluggish - sometimes even losing keystrokes and control of the mouse for a few milliseconds at a time (I had to go back and correct this post due to missing keystrokes that I did make but didn't register).
I'm considering changing distro if this isn't fixed soon.
[update:9mar10]: See possible fixes here
I have the same issue. At first I noticed a process "genome-do" was using 200% of my cpu time. After managing to kill that I'm still having some issues.
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